Which one of the following statements concerning glucose metabolism is correct?

(A) The conversion of Glucose to lactate occurs
only in the R.B.C
(B) Glucose enters most cells by a mechanism in
which Na+ and glucose are co-transported
(C) Pyruvate kinase catalyses an irreversible
reaction
(D) An elevated level of insulin leads to a
decreased level of fructose 2, 6-bisphosphate
in hepatocyte